There has been growing interest in the use of cannabis-based products for the treatment of a wide range of diseases, including epilepsy. A number of studies were published during the last 5 years
demonstrating efficacy of purified CBD for the control of a large spectrum of seizure-types, particularly those observed in severe childhood epilepsies, such as Lennox- Gastaut and Dravet syndromes. This book, co-authored by leaders in the field of epileptology, critically reviews recent data from clinical trials. Authors discuss issues related to pharmacology, drug interactions, efficacy, potential adverse events and
long-term effects on development and behaviour. Child and adult neurologists and all clinicians contributing to epilepsy care will find useful information on the best practices, when using purified CBD for the treatment of
Since 1984, the year of the publication of its first edition, the famous "Blue Guide" has been the international reference for paediatricians and neuropaediatricians with regard to epileptic syndromes in infants, children and adolescents.
This 6th edition reviews some of the most noteworthy developments in the field, particularly in epileptic syndromes, but also focuses on the genetic aspects of the syndromes and their development. Progress brought about by advances in neuroimaging is also discussed in addition to specific etiologies such as parasitic diseases and immune and autoimmune diseases.
The different backgrounds of the contributors - coordinators and authors - ensure that the book's longstanding reputation for objectivity and seriousness, built over almost 35 years, remain well-deserved.
This book written by the current leading specialists is recognized worldwide as the international reference in epilepsy.
The need for neuropathology reviews in epilepsy surgery tissues steadily increases. However, textbooks and case presentations highlighting and focusing on this specific topic are rare.
The authors of this book reviewed their professional experience in surgical and post-mortem neuropathology studies to compile a coherent summary of :
current classification schemes,
for major histopathological entities of brain lesions encountered in modern epilepsy surgery programs, which is hippocampal sclerosis, brain tumours associated with early epilepsy onset, malformations of cortical development, brain inflammation and malformative vascular lesions. They did not intend to be exhaustive but rather representative of the main lesions and pathologies encountered.
Thirty-two illustrated cases constitute the core of this book and will be very helpful in current practice.
A comprehensive review of visual impairment in children and possible solutions
The rising number of cases in visual disorders during development, over the last decade, has strongly influenced approaches to diagnosis and rehabilitation.
This book provides an update on paediatric neurological disorders with cerebellar involvement.
The opening section of the volume is dedicated to the structure and function of cerebellum: the specific development of this organ, unlike other str
This work, which results from the Marburg colloquium, chose to focus on one of the more common forms of partial epilepsies and for which surgery is often the treatment of choice, namely the mesial temporal lobe epilepsies.
The theme of the Cleveland colloquium which took place in May 2010 was extratemporal lobe epilepsy surgery.
Patients with refractory extratemporal lobe epilepsy, particularly those in whom imaging examinations did not reveal any brain le
A current update on the use of clinical neuropsychology in epilepsy and its future outlook
Clinical neurology has still not managed to clear a way in the daily practice with patients with all types of epilepsy despite significant advances in c
More than half of epilepsies start before the age of 20 years and nearly 25% of them are refractory.
A tiny proportion of them are even labelled a "rare illness", i.e. one affecting less than 200,000 people in the United States or less than 5
The book provides a comprehensive review and update of the newest diagnostic and therapeutic tools in paediatric neurology. Special attention is paid to neuroradiologic and neurophysiologic techniques and to their clinical application, with guidel
The aim of this publication is to demonstrate the effect of the neural networks on cognitive functions and behavioural patterns during the development phase of a child.
Taking as a basis the previous publication in this series dedicated to bra
This volume provides updated information on epilepsy genes, on the clinical picture of genetic epilepsies discovered so far, and on conceptual advances in the complicated area of genotype-phenotype correlations.
Recent studies on monogenic epi
Epileptic encephalopathies have been discussed in different publications but mainly in relation to childhood. However, recent years have shown an increase of the life expectancy and social integration of patients with epileptic encephalopathies. Although the treatment goals remain the same regardless of age, the clinical symptoms, EEG-abnormalities, mental and behavioural aspects, side effect profiles of antiepileptic drugs change over time, requiring evolving and sometimes innovative therapies. Moreover, the social issues are important to consider for the maintenance of consistency in the delivery of care.
The present book covers the long-term evolution of epileptic encephalopathies in terms of clinical symptomatology, cognitive functions, treatment strategies and social care options. It will help clinicians, healthcare practitioners and social service professionals to understand better the natural history of epileptic encephalopathies, to identify specific management issues and to develop appropriate care strategies for this category of patients.
When epilepsy is diagnosed, it is important to try to control the seizures and the social consequences of the disease over several months both in childhood and later in life.
Although difficult to measure, these consequences can be assessed th
This book provides an update on the progress made in the diagnosis, neurobiology and pharmacological treatment of autism and the rehabilitation of sufferers. It looks set to have an influence on professional practices and thus modernise the
Cognitive and behavioural neurology is increasingly the focus of attention from the neurosciences, both in adults and children.This field combines a number of specialties to ensure that neurological conditions are approached from differ
Facial Rejuvenation enables a general overview on specific subjects.
It constitutes a useful tool which offers information allowing the reader to progress, always from an ethical perspective, and to provide a global medical and esthetical trea
A reference book on diagnosis, consequences and management on neonatal and infantile seizures
There is a very high incidence of seizures during the first two years of life. This may reflect multiple etiologies depending on the circumstances un
In 1997, Jean AICARDI, one of the most brilliant child neurologists of our era, commented on "How the view has changed" in the field of pediatric epilepsy surgery: "Surgery for epilepsy has now become a realistic therapeutic option for selected children and the field is likely to increase in the near future. It is now realised that procrastination, in the hope that new antiepileptic drugs will become efficacious, is not justified for some forms of epilepsy that can often be recognised from onset or after a relatively short course. It is also becoming clear that surgery is not reserved for a highly selected population of patients with normal intelligence and focal seizures, but may also help a proportion of more severe epilepsies if a realistic view of the problem and perspectives is taken by the partners".
Twenty years later, the most obvious and probably still the strongest reasons against epilepsy surgery in children are cultural and psychological. This book, written by members of the ad hoc ILAE Task Force for pediatric epilepsy surgery and experts in the field, is the result of continued collaborative working between pediatric epilepsy surgery centres over the years. Authors critically review all available data and set out the key elements of presurgical evaluation, the specific electro-clinical presentations per etiology, the range of outcomes to be monitored, and the surgical techniques used today.
What becomes obvious when reviewing all available data is that the key to optimized outcome in children with epilepsy is early appropriate recognition of possible surgical candidates and timely referral to centres with expertise.
Progressive myoclonus epilepsy strikes healthy children and has a slow yet devastating impact upon their lives. Almost all forms are caused by single gene defects, the majority of which were identified during the genomic era.
The third volume of the series of Atlases deals with the use and usefulness of electroencephalography (EEG) in neurology.
While EEG is universally recognized as a first-order investigation method in epilepsy (see Volume 2), and as an important contributor in sleep medicine, practical neurology has tended to neglect the value of this classical and established neurophysiological tool. A rich, extensively commented and analyzed collection of EEG plates is presented here.
The reader will be compelled to remember that EEG is the easiest way to assess parameters like state of vigilance, risk of seizure activity, type and degree of functional impairment, in a very clinical and practical setting. The authors cover many aspects of neurological practices where the EEG may help in diagnosis and treatment: metabolic and other encephalopathies, infectious and inflammatory conditions, vascular disorders. It is particularly useful -and difficult- to distinguish between epileptic phenomena and EEG changes associated with metabolic abnormalities: a careful assessment of the EEG is of paramount practical importance here. Migraine is not always simple and there are many overlaps with other types of neurological diseases: the EEG may play a major part in helping the clinician in doubtful cases. Similarly, the diagnosis of dementia does certainly not rest on the EEG but many particular aspects concerning diagnostic overlaps or copathologies are aptly explored by the EEG. Lastly, even the neurosurgeon may need the EEG to monitor trauma, tumor, bleeding...
This Atlas will provide both examples and guidelines for the optimal use of the EEG in neurology.
Fully updated and revised, the 3rd edition of the Atlas of Electroencephalography volume 1: Awake and Sleep EEG, activation procedures and artifacts retains the format and presentation that made the previous editions successful.
It is the most comprehensive EEG atlas on activation procedures, artifacts and normal EEG, covering the full spectrum of normal and unusual patterns observed during wakefulness and sleep, in children and adults. It will significantly help the visual analysis of EEG by neurologists and other specialists as well as technologists.
Electroencephalograms are shown in their native format, exactly as they appear in daily practice. Each plate is analyzed, in order to highlight the most significant elements to be used in diagnosis and interpretation. This 3rd edition includes a total of 180 EEG plates.
Philippe Gélisse and Arielle Crespel are neurologists running the Epilepsy Unit at the Montpellier University Hospital, in France. Both have extensive national and international experience in teaching about EEG and they have written numerous scientific publications in the field.
Fully revised and updated, this second edition of the second volume of the Atlases of electroencephalography series includes more than 2/3 new high-quality digital figures. A new Classification approach to epileptic seizures and to the epilepsies became official in 2017. Several aspects in terms of terminology have been included in this book and most of the chapters have been rewritten.
The second volume of this series on the practical use and interpretation of EEG focuses on epilepsies in their diversity. It is richly illustrated, and each EEG plate is analyzed in order to highlight the most significant elements to be used both for the diagnosis and interpretation. The originality of this textbook lies in its patient-based approach, thereby avoiding the pitfall of a formal presentation of EEG documents without their clinical context. Hence electroencephalography is placed at the core of the diagnostic and therapeutic discussion concerning patients with epilepsy.
Given the practical orientation of this Atlas, the focus is on common forms of epilepsies; nevertheless, some less common, more intriguing forms have also been illustrated. A synthetic text summarizes the present approach to the main epilepsy categories.
This Atlas is designed for all the actors who may be involved with patients with epilepsy. Physicians who deal with EEG will find it a valuable tool to improve the education of their early years, to help them with their interpretations later on, and for teaching purposes when more experienced. But it will also prove useful for all the physicians interested in epilepsy, as well as EEG technologists intent on providing quality recordings, and other professionals. Thorough understanding of human epilepsies requires extensive knowledge of their EEG correlates.
In the last years, clinical data, neurophysiological and imaging investigations, as well as genetic studies have renewed the interest on ESES. In addition, experimental findings from sleep research have opened fascinating perspectives on some possible pathophysiological mechanisms involved in this condition.
These issues are presented and discussed in this book by clinicians, neurophysiologists, sleep physiologists and geneticists. They all have been working on ESES with the aim to provide an updated overview of this special syndrome in the light of recent research.