Paolo Sassone Corsi

  • Le cas du Hasard est né de l'envie des deux auteurs de prolonger un échange débuté lors d'un dîner amical, avec vue sur l'océan Pacifique. Leur volonté d'approfondir la discussion animée d'un soir a donc donné lieu à une correspondance des plus singulières. Si l'ouvrage s'ouvre sur une tentative de définir l'ADN - que le biologiste compare à une partition de musique tandis que l'écrivain y voit plutôt une prophétie -, les sujets abordés sont innombrables. Ce qui frappe, au-delà de l'étendue des connaissances scientifiques de l'un et de la pertinence du regard de l'autre, est la poésie de l'ensemble, car Erri De Luca et Paolo Sassone-Corsi évoquent tour à tour Brodsky, la baie de Naples, Beethoven ou le couple Curie pour nous faire partager leur vision de l'univers. Leur enthousiasme à réinventer ainsi le monde se reflète dans l'écriture, allègre et joyeuse, pour le plus grand bonheur du lecteur.

  • Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.

  • Recent years have seen spectacular advances in the filed of epigenetics. These have attracted the interest of researchers in many fields and evidence connecting epigentic regulation to brain functions has been accumulationg. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. A variety of studies have centered on the molcular mechanisms implicated in epigentic control and how these may operte in concert. It will be critical to unravel how specifity is achieved. The focus of this volume is on critical epigenetic regulation and chromatin remodeling events that occur in the nervous system and on the presumed mechanisms that operate within neurons to translate them into long-lasting neuronal responses.

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